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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAPKAPK5
All Species:
22.42
Human Site:
T25
Identified Species:
41.11
UniProt:
Q8IW41
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IW41
NP_003659.2
473
54220
T25
E
E
Y
S
I
N
W
T
Q
K
L
G
A
G
I
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001102910
666
74053
T220
E
E
Y
S
I
N
W
T
Q
K
L
G
A
G
I
Dog
Lupus familis
XP_534678
804
89494
T356
E
E
Y
N
I
N
W
T
Q
K
L
G
A
G
I
Cat
Felis silvestris
Mouse
Mus musculus
O54992
473
54134
T25
E
E
Y
S
I
N
W
T
Q
K
L
G
A
G
I
Rat
Rattus norvegicus
Q66H84
384
43204
G25
A
L
G
A
P
A
L
G
G
A
P
A
P
G
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521063
278
31941
Chicken
Gallus gallus
Q5F3L1
789
89022
A31
N
A
N
L
T
G
H
A
E
K
V
G
I
E
N
Frog
Xenopus laevis
NP_001085020
377
43533
Q25
P
V
Q
Q
Q
Q
Q
Q
Q
Q
L
K
S
S
L
Zebra Danio
Brachydanio rerio
NP_001002336
471
53898
T25
E
E
Y
N
I
N
W
T
Q
K
L
G
A
G
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49071
359
41383
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_500006
366
41523
I14
P
V
T
Q
D
Y
R
I
S
R
K
V
L
G
V
Sea Urchin
Strong. purpuratus
XP_001194739
473
54175
T26
E
D
Y
T
I
D
W
T
Q
K
L
G
T
G
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9ZV15
583
64702
G137
L
K
D
I
Y
S
V
G
R
K
L
G
Q
G
Q
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
70.7
58
N.A.
97.2
34.4
N.A.
57.2
21.1
34
87
N.A.
32.3
N.A.
34.6
56
Protein Similarity:
100
N.A.
70.7
58.3
N.A.
98.7
52.8
N.A.
58.1
35.3
52
94.2
N.A.
49.2
N.A.
52.4
72.3
P-Site Identity:
100
N.A.
100
93.3
N.A.
100
6.6
N.A.
0
13.3
13.3
93.3
N.A.
0
N.A.
6.6
73.3
P-Site Similarity:
100
N.A.
100
100
N.A.
100
20
N.A.
0
26.6
33.3
100
N.A.
0
N.A.
20
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
37.3
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
8
0
8
0
8
0
8
0
8
39
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
8
0
8
8
0
0
0
0
0
0
0
0
0
% D
% Glu:
47
39
0
0
0
0
0
0
8
0
0
0
0
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
8
0
0
8
0
16
8
0
0
62
0
70
0
% G
% His:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
8
47
0
0
8
0
0
0
0
8
0
47
% I
% Lys:
0
8
0
0
0
0
0
0
0
62
8
8
0
0
0
% K
% Leu:
8
8
0
8
0
0
8
0
0
0
62
0
8
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
8
16
0
39
0
0
0
0
0
0
0
0
8
% N
% Pro:
16
0
0
0
8
0
0
0
0
0
8
0
8
0
0
% P
% Gln:
0
0
8
16
8
8
8
8
54
8
0
0
8
0
8
% Q
% Arg:
0
0
0
0
0
0
8
0
8
8
0
0
0
0
0
% R
% Ser:
0
0
0
24
0
8
0
0
8
0
0
0
8
8
0
% S
% Thr:
0
0
8
8
8
0
0
47
0
0
0
0
8
0
0
% T
% Val:
0
16
0
0
0
0
8
0
0
0
8
8
0
0
16
% V
% Trp:
0
0
0
0
0
0
47
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
47
0
8
8
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _